Immunological, mediated with IgE and associated with herpesvirus infection, phenotypes of nephrotic syndrome among children
E. V. Churyukina,
L. F. Ovsyannikova https://doi.org/10.24412/2500-1175-2021-1-24-34
Abstract
The development of nephrotic syndrome (NS) among children is accompanied by the observable changes of the immune status, which are manifested by the disbalance of lymphocytes subpopulations, dysimmunoglobulinemia and the disturbance of the metabolic activity of phagocytes. Immunological, associated with higher level of total IgE and HVI phenotypes of nephrotic syndrome among children were identified. NS of hyper IgE-phenotype is characterized by the increase of general IgE level in the peripheral blood. NS associated with HVI is characterized by the activation of humoral antiherpetic immunity, which was manifested by the presence of active HVI markers in the blood (Ab IgM and/or Ab IgG of low avidity to VH) on the background of clinical manifestations of HVI: the presence of fever, lymphadenopathy, enlargement of liver and spleen, skin and mucous rashes. The addition of antivirus drugs to the standard basic treatment of NS stopped the clinical signs of HVI exacerbation and optimized NS therapy.
About the Authors
R. A. BelovolovaRussian Federation
Rostov-on-Don
G. M. Letifov
Russian Federation
Rostov-on-Don
L. V. Mavrina
Russian Federation
Rostov-on-Don
E. V. Belovolova
Russian Federation
Rostov-on-Don
A. P. Titov
Russian Federation
Rostov-on-Don
E. V. Churyukina
Russian Federation
Ella V. Churyukina, PhD, Docent, Head of the Division of Allergic and Autoimmune diseases of Rostov State Medical University, Rostov-on-Don, Russian Federation; Associate Professor of the Department of Clinical Immunology, Allergology and laboratory diagnostics of Kuban State Medical University
Kommunisticheskiy avenue 27, flat 131, Rostov-onDon, 344091, Russia
L. F. Ovsyannikova
Russian Federation
Rostov-on-Don
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Review
For citations:
Belovolova R.A., Letifov G.M., Mavrina L.V., Belovolova E.V., Titov A.P., Churyukina E.V., Ovsyannikova L.F. Immunological, mediated with IgE and associated with herpesvirus infection, phenotypes of nephrotic syndrome among children. Allergology and Immunology in Paediatrics. 2021;(1):24-34. https://doi.org/10.24412/2500-1175-2021-1-24-34
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