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Allergology and Immunology in Paediatrics

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Tryptase in children in the practice of an allergist

https://doi.org/10.24412/2500-1175-2021-1-4-14

Abstract

The normal serum tryptase level is 0–11.4 ng/ml. Hypertryptasemia occurs with anaphylaxis, systemic mastocytosis, and cutaneous mastocytosis in children. Recently, mast cell activation syndromes are increasingly being diagnosed. The article discusses the main reasons for the increase in the concentration of tryptase in children. Allergists must correctly interpret its causes.

About the Author

D. Sh. Macharadze
Рeoples Friendship University of Russia (RUDN University)
Russian Federation

Dali Sh. Macharadze, MD, Professor of the Department of Nursing 

Miklukho-Maclay st., 6, 117198, Moscow, Russia



References

1. Maurer M., Köberle M., Metz M., Biedermann T. Mast cells: Promoters of health and modulators of disease. J Allergy Clin Immunol. 2019; 144(4S):S1–S3. doi: 10.1016/j.jaci.2019.01.048.

2. Wilcock A., Bahri R., Bulfone-Paus S., Arkwright P.D. Mast cell disorders: From infancy to maturity. Allergy. 2019; 74(1):53–63. doi: 10.1111/all.13657.

3. Platzgummer S., Bizzaro N., Bilò M.B., et al. Recommendations for the Use of Tryptase in the Diagnosis of Anaphylaxis and Clonal Mastcell Disorders. Eur Ann Allergy Clin Immunol. 2020; 52(2):51–61. doi: 10.23822/EurAnnACI.1764-1489.133.

4. Lobbes H., Reynaud Q., Mainbourg S., Lega J.C., Durieu I., Durupt S. Dosage de la tryptase: un guide d'utilisation pour le clinicien [Tryptase: A practical guide for the physician]. Rev Med Interne. 2020; 23:S0248– 8663(20)30204-6. French. doi: 10.1016/j.revmed.2020.06.006.

5. Valent P., Akin C., Bonadonna P., et al. . Mast cell activation syndrome: Importance of consensus criteria and call for research. J Allergy Clin Immunol. 2018; 142(3):1008–1010. doi: 10.1016/j.jaci.2018.06.004.

6. Weiler C.R., Austen K.F., Akin C., et al. AAAAI Mast Cell Disorders Committee Work Group Report: Mast cell activation syndrome (MCAS) diagnosis and management. J Allergy Clin Immunol. 2019; 144(4):883– 896. doi: 10.1016/j.jaci.2019.08.023.

7. Lyons J., Stotz S., Chovanec J. et al. A common haplotype containing functional CACNA1H variants is frequently coinherited with increased TPSAB1 copy number. Genet Med. 2018; 20(5):503–512. doi: 10.1038/gim.2017.136.

8. Bonadonna P., Scaffidi L., Boni E. Tryptase values in anaphylaxis and insect allergy. Curr Opin Allergy Clin Immunol. 2019; 19(5):462–467. doi: 10.1097/ACI.0000000000000569.

9. Ruëff F., Przybilla B., Biló M.B., et al. Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase — a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity. J Allergy Clin Immunol. 2009; 124(5):1047–54. doi: 10.1016/j.jaci.2009.08.027.

10. Schliemann S., Seyfarth F., Hipler U.-C., Elsner P. Impact of age and heterophilic interference on the basal serum tryptase, a risk indication for anaphylaxis, in 1092 dermatology patients. Acta Derm Venereol 2012; 92:484–9. doi: 10.2340/00015555-1245.

11. Valent P., Sperr W.R., Sotlar K., Reiter A., Akin C., Gotlib J., et al. The serum tryptase test: an emerging robust biomarker in clinical hematology. Expert Rev Hematol. 2014; 7:683–90. doi: 10.1586/17474086.2014.955008.

12. Mulé P., Gabrielli S., Upton J., Em A., Ben-Shoshan M. Anaphylaxis to goat/sheep's milk in a 4-year-old boy tolerant to cow's milk. BMJ Case Rep. 2020; 13(1):e232844. doi: 10.1136/bcr-2019-232844.

13. Broesby-Olsen S. Mastocytosis: urticaria pigmentosa and mastocytosis in the skin. Global atlas of skin allergy. 2019, 177–179.


Review

For citations:


Macharadze D.Sh. Tryptase in children in the practice of an allergist. Allergology and Immunology in Paediatrics. 2021;(1):4-14. (In Russ.) https://doi.org/10.24412/2500-1175-2021-1-4-14

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ISSN 2500-1175 (Print)
ISSN 2712-7958 (Online)