Study of the interferon profile in children with bronchial asthma
https://doi.org/10.53529/2500-1175-2025-3-66-73
Abstract
Introduction. Bronchial asthma in children is an urgent medical problem. Currently, there are separate clusters of BA variants and various phenotypes. ARVI is the most frequent trigger of BA exacerbations, which makes the study of interferon status relevant.
Methods. A study of IFN-α and IFN-γ in the blood serum of children with AIBA (n = 60) and VIBA (n = 10).
Results. An increase in IFN-γ was found in AIBA by 1.9 times and in VIBA by 1.7 times. An increase in IFN-α was observed in both AIBA (4.7 times, 2.95 ± 0.73 pg/ml) and VIBA (9.9 tim es, 6.24 ± 1.32 pg/ml). A decrease in IFN-γ in the blood serum was observed in moderate AIBA (1.23 ± 1.59 pg/ml) and severe AIBA (0.76 ± 0.64 pg/ml).
Conclusion. Decreased IFN-γ content is an important factor in the severe course of AIB. As an additional marker for the diagnosis of BA phenotype, the use of IFN-α / IFN-γ ratio is proposed.
Supporting agencies: The authors declare that there is no funding for the study
About the Authors
I. N. Serdinskaya
State Autonomous Healthcare Institution “Children’s City Polyclinic No. 9”
Russian Federation
Russian Federation
Inna Nikolaevna Serdinskaya, pediatrician
420133; Adoratsky str., 6; Kazan
Kh. M. Vakhitov
Federal state budgetary educational institution of higher education «Kazan state medical university» of the Ministry of health of the Russian Federation
Russian Federation
Russian Federation
Khakim Muratovich Vakhitov, Dr. Sci., Professor
Department of Hospital Pediatrics
420012; Butlerova str., 49; Kazan
E. V. Agafonova
Federal budgetary institution of science “Kazan scientific research institute of epidemiology and microbiology” of Rospotrebnadzor
Russian Federation
Russian Federation
Elena Valentinovna Agafonova, Cand. Sci., Associate Professor, Head clinical and diagnostic laboratory
Department of Propaedeutics of Childhood Diseases and Faculty Pediatrics
420015; B. Krasnaya str., 67; Kazan
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For citations:
Serdinskaya I.N., Vakhitov Kh.M., Agafonova E.V. Study of the interferon profile in children with bronchial asthma. Allergology and Immunology in Paediatrics. 2025;(3):66-73. (In Russ.) https://doi.org/10.53529/2500-1175-2025-3-66-73
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