Preview

Allergology and Immunology in Paediatrics

Advanced search

Obvious and hidden ways of sensitization for children with food allergies and atopic dermatitis

https://doi.org/10.24412/2500-1175-2021-2-25-30

Abstract

Recent decades see a steady increase in the number of patients suffering from food allergies worldwide. Children have a variety of clinical symptoms of food allergy. Some patients have local allergic reaction in the oral cavity, other — atopic dermatitis or gastrointestinal allergy, and sometimes there is the food anaphylaxis that put child’s life in danger. Atopic dermatitis is among the most common food allergy symptom. We all know that atopic dermatitis is a multifactorial chronic disease characterized by skin itching and inflammation. Allergens in children food intake are considered to be the main factors to provoke atopic dermatitis at an early age, but sometimes not only oral allergens are the main triggers of the disease. Nowadays we get more data about inhalation and transdermal ways of sensitization with atopic dermatitis.

Resent global scientific discoveries in molecular allergology changed the awareness of allergen structure and new ways to detect allergy. Scientists proved the direct connection between recurrent and difficult to treat signs of atopic dermatitis and IgE-dependent allergic reactions. That forces doctors to choose ISAC-112 ImmunoCAP test to treat patients with severe skin lesions to clarify the spectrum of sensitization.

Objective: to describe a clinical case and to stress the importance of clarifying all possible allergens that can sensitize a patient with symptoms of atopic dermatitis, detected by ISAC-112 ImmunoCAP test.

About the Authors

T. S. Lepeshkova
Federal State Budgetary Educational Institution of Higher Professional Education «The Urals State Medical University» of the Ministry of Health of Russia
Russian Federation

Tatiana S. Lepeshkova, candidate of medical sciences, associate Professor Department of polyclinic Pediatrics and Pediatrics faculty of advanced  training and  retraining 

Repina str., aр. 3, Ekaterinburg, 620028, Russia 



E. V. Andronova
«Semeynuy Doctor»
Russian Federation

Magnitogorsk



L. R. Zakirova
Federal State Budgetary Educational Institution of Higher Professional Education «The Urals State Medical University» of the Ministry of Health of Russia
Russian Federation

Ekaterinburg



References

1. Federal’nye klinicheskie rekomendatsii «Atopycheskiy dermatit u detey».2016. https://www.pediatr-russia.ru/information/klin-rek (In Russ)

2. Jonathan M. Spergel., Amy S. Paller. Atopic dermatitis and the atopic march//J. Allergy Clin Immunol. 2003;Vol. 112. (Suppl 6): 118–127.

3. Smolkin U.S., Balabolkin I.I., Gorlanov I.A. i dr. Soglasitelnii document ADAIR: atopycheskiy dermatit u detey — obnovlenie 2019 (kratkaya versiya). Allergologiya i immunologiya v pediatrii.2020; 1(60): 12–13. (InRuss)]

4. Pampura A.N., Varlamov E.E., Konyukova N.G. Pishchevaya allergiya u detey rannego vozrasta //Pediatriya. Zhurnalim.G.N. Speranskogo.2016; 3(95): 152–157 (In Russ)

5. WAO-ARIA-GA2LEN consensus document on molecular-based allergy diagnostics // World Allergy Organization Journal. 2020; Vol. 13. (Suppl 2): 1–47.

6. Pampura A.N., Esakova N.V. Anafilaksiya u detey. M.:ID «Medpraktika-M», 2020:123–126.(In Russ)

7. Ruethers T., Taki A.C, Johnston E.B. et al. Seafood allergy: A comprehensive review of fish and shellfish allergens // J. Mol. Immunol.2018; Vol. 100: 28–57.

8. Food Allergy and Anaphylaxis Guidelines. Translating knowledge into clinical practice. EAACI. 2014: 276.

9. Lopata A.L., Jeebhay M.F. Airborne seafood allergens as a cause of occupational allergy and asthma // J. Curr. Allergy Asthma Rep. 2013;Vol. 13 (Suppl 13): 288–297.

10. Korovkina E.S., Mokronosova M.A. Allergiya k kleshcham domashnei pili s pozitsii moleculyarnoi allergologii // Meditsinskaya immunologiya. 2012; 4(14): 279–288 (InRuss)

11. Pampura A.N. Problemi i perspektivi detskoi allergologii // Rossiiskii vestnik perinatologii i pediatrii.2015; 1(60):7–15 (In Russ)

12. Lehmann K., Schweimer K., Reese G. et al. Structure and stability of 2S albumin-type peanut allergens: implications for the severity of peanut allergic reactions // J. Biochem. 2006: Vol. 395. (Suppl 3): 463–472.

13. Blanc F., Adel-Patient К., Drumare M.-F. et al. Capacity of purified peanut allergens to induce degranulation in a functional in vitro assay: Ara h 2 and Ara h 6 are the most efficient elicitors // Clin Exp Allergy.2009; Vol. 39. (Suppl 8): 1277–1285.

14. Flinterman A.E., van Hoffen Е., den Hartog Jager C.F.еt al. Children with peanut allergy recognize predominantly Ara h2 and Ara h6, which remains stable over time //ClinExp Allergy. 2007; Vol. 37. (Suppl 8): 1221–1228.

15. Kukkonen A.K., Pelkonen A.S., Mäkinen-Kiljunenet S. et al. Ara h 2 and Ara h6 are the best predictors of severe peanut allergy: a double-blind placebo-controlled study // J. Allergy. 2015; Vol. 70. (Suppl 10): 1239–1245.

16. SichererS.H., Monoz-Furlong A., De Simone J. et al. The US peanut and tree nut allergy registry: characteristics of reactions in schools and day care // Journal of Pediatrics.2001; Vol. 138. (Suppl 4):560–565.


Review

For citations:


Lepeshkova T.S., Andronova E.V., Zakirova L.R. Obvious and hidden ways of sensitization for children with food allergies and atopic dermatitis. Allergology and Immunology in Paediatrics. 2021;(2):25-30. (In Russ.) https://doi.org/10.24412/2500-1175-2021-2-25-30

Views: 257


ISSN 2500-1175 (Print)
ISSN 2712-7958 (Online)