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Population of Th1/Th17 lymphocytes in the prognosis of the effectiveness of biological therapy in children with autoimmune diseases

https://doi.org/10.53529/2500-1175-2025-4-101-104

About the Authors

S. V. Petrichuk
National Medical Research Center for Children’s Health, Federal State Autonomous Institution of the Ministry of Health of the Russian Federation
Россия

Moscow, Lomonosovsky Prospect, Building 2, Building 1



T. V. Radigina
National Medical Research Center for Children’s Health, Federal State Autonomous Institution of the Ministry of Health of the Russian Federation
Россия

Moscow, Lomonosovsky Prospect, Building 2, Building 1



D. G. Kuptsova
National Medical Research Center for Children’s Health, Federal State Autonomous Institution of the Ministry of Health of the Russian Federation
Россия

Moscow, Lomonosovsky Prospect, Building 2, Building 1



O. V. Kurbatova
National Medical Research Center for Children’s Health, Federal State Autonomous Institution of the Ministry of Health of the Russian Federation
Россия

Moscow, Lomonosovsky Prospect, Building 2, Building 1



M. V. Konyashin
National Medical Research Center for Children’s Health, Federal State Autonomous Institution of the Ministry of Health of the Russian Federation
Россия

Moscow, Lomonosovsky Prospect, Building 2, Building 1



A. P. Fisenko
National Medical Research Center for Children’s Health, Federal State Autonomous Institution of the Ministry of Health of the Russian Federation
Россия

Moscow, Lomonosovsky Prospect, Building 2, Building 1



References

1. Chanchlani N., Lin S., Bewshea C., Hamilton B., Thomas A., Smith R., Roberts C., Bishara M., Nice R., Lees C.W., Sebastian S., Irving P.M., Russell R.K., McDonald T.J., Goodhand J.R., Ahmad T., Kennedy N.A.; PANTS Consortium. Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn’s disease: 3-year data from the prospective, multicentre PANTS cohort study. Lancet Gastroenterol Hepatol. 2024; 9 (6): 521–538. https://doi.org/10.1016/S2468-1253(24)00044-X.

2. Yang P., Qian F.Y., Zhang M.F., et al. Th17 cell pathogenicity and plasticity in rheumatoid arthritis. J Leukoc Biol. 2019; 106 (6): 1233–1240. https://doi.org/10.1002/JLB.4RU0619-197R.

3. Kuklina E.M., Glebezdina N.S. Markers of Th1 polarized Th17 cells (literature review). Acta biomedica scientifica. 2023; 8 (3): 55–62. https://doi.org/10.29413/ABS.2023-8.3.5. (In Russ.)

4. Quirant-Sánchez B., Presas-Rodriguez S., Mansilla M.J., et al. Th1Th17CM Lymphocyte Subpopulation as a Predictive Biomarker of Disease Activity in Multiple Sclerosis Patients under Dimethyl Fumarate or Fingolimod Treatment. Mediators Inflamm. 2019; 2019: 8147803. Published 2019 Jun 26. https://doi.org/10.1155/2019/8147803.

5. Cao H., Diao J., Liu H., Liu S., Liu J., Yuan J., Lin J. The Pathogenicity and Synergistic Action of Th1 and Th17 Cells in Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2023 May 2; 29 (5): 818–829. https://doi.org/10.1093/ibd/izac199. PMID: 36166586.

6. Petrichuk S.V., Miroshkina L.V., Semikina E.L., Toptygina A.P., Potapov A.S., Tsimbalova E.G., Radygina T.V. Indiсators of the lymphocyte subsets as efficiency predictors of therapy with inhibitors of TNFα in children with inflammatory bowel disease. Medical Immunology (Russia) / Meditsinskaya Immunologiya. 2018; 20 (5): 721–730. https://doi.org/10.15789/1563-0625-2018-5-721-730. (In Russ.)

7. Radygina T.V., Kuptsova D.G., Kurbatova O.V., Petrichuk S.V., Semikina E.L., Fisenko A.P., Abdullaeva L.M., Bursagova B.I. Features of parameters of cellular immune depending on the activity of foci of demyelination in children with multiple sclerosis. Medical Immunology (Russia) / Meditsinskaya Immunologiya. 2023; 25 (5): 1019–1026. https://doi.org/10.15789/1563-0625-FOP-2777. (In Russ.)

8. Kuptsova D.G., Radigina T.V., Kurbatova O.V., Materikin A.I., Epishev R.V., Opryatin L.A., Khotko A.A., Murashkin N.N., Petrichuk S.V. Content of CD4+Т cell populations in predicting the efficacy of biological therapy for psoriasis in children. Medical Immunology (Russia) / Meditsinskaya Immunologiya. 2023; 25 (5): 1071–1078. https://doi.org/10.15789/1563-0625-COC-2704. (In Russ.)

9. Kuklina E.M., Glebezdina N.S. Identification of Th1-polarized Th17 cells: solving the problem. Medical Immunology (Russia) / Meditsinskaya Immunologiya. 2023; 25 (4): 731–734. https://doi.org/10.15789/1563-0625-IOT-2770. (In Russ.)


Review

For citations:


Petrichuk S.V., Radigina T.V., Kuptsova D.G., Kurbatova O.V., Konyashin M.V., Fisenko A.P. Population of Th1/Th17 lymphocytes in the prognosis of the effectiveness of biological therapy in children with autoimmune diseases. Allergology and Immunology in Paediatrics. 2025;(4):101-104. (In Russ.) https://doi.org/10.53529/2500-1175-2025-4-101-104

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ISSN 2500-1175 (Print)
ISSN 2712-7958 (Online)