adairАллергология и Иммунология в ПедиатрииAllergology and Immunology in Paediatrics2500-11752712-7958Ассоциация детских аллергологов и иммунологов России10.53529/2500-1175-2022-3-34-41adair-79Research ArticleКЛИНИЧЕСКИЕ СЛУЧАИMEDICAL CASESТри заболевания T2-воспаления у подростка: астма, эозинофильный эзофагит и хронический полипозный риносинусит (Клинический случай)Three T2 inflammatory diseases in adolescents: asthma, eosinophilic eso- phagitis, and chronic polypous rhinosinusitis (Clinical Case)https://orcid.org/0000-0001-5999-7085МачарадзеД. Ш.MacharadzeD. Sh.

Дали Шотаевна Мачарадзе, д. м. н., профессор

кафедра сестринского дела

117198

ул. Миклухо-Маклая, д. 6

Москва

117198

6, Miklukho-Maklaya str.

Moscow

dalim_a@mail.ruhttps://orcid.org/0000-0002-8785-2825KулумбеговБ. Г.KulumbegovB. G.

Бидзина Георгиевич Кулумбегов, ассоциированный профессор, аллерголог

0719

ул. Любляна, 2

Тбилиси

0719

2, Lubliana str.

Tbilisi

kulumbegov@gmail.comФГАОУ ВО «Российский университет дружбы народов»РоссияPeoples’ Friendship University of RussiaRussian FederationКавказский международный университет; Центр аллергологии и иммунологииГрузияCaucasus International UniversityGeorgia202231072023033441Copyright © Мачарадзе Д.Ш., Kулумбегов Б.Г., 20232023Мачарадзе Д.Ш., Kулумбегов Б.Г.Macharadze D.S., Kulumbegov B.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://adair.elpub.ru/jour/article/view/79

   Давно известно, что такие коморбидные заболевания, как, например, хронический полипозный риносинусит и ожирение, неблагоприятно влияют на патофизиологию бронхиальной астмы, ухудшают ответ на терапию и снижают качество жизни больных. Выявление и эффективное лечение сопутствующих заболеваний будет способствовать улучшению контроля над астмой и снижению частоты обострений. Появляется все больше исследований, которые указывают также на тесную патофизиологическую связь с аллергическими заболеваниями эозинофильного эзофагита. По последним данным, в развитии аллергических заболеваний (астма, аллергический ринит, атопический дерматит, пищевая аллергия), хронического полипозного риносинусита, а также эозинофильного эзофагита ключевым является T2 иммунный ответ (Т2-воспаление) как у детей, так и у взрослых. Своевременная диагностика воспалительных состояний T2-воспаления может помочь в выборе оптимального лечения таких больных. Здесь мы описываем коморбидные состояния, выявленные у подростка с контролируемой бронхиальной астмой и обсуждаем особенности их клинического течения.

   Цель данной работы — повысить осведомленность практикующих врачей о коморбидных заболеваниях: эозинофильном эзофагите и хроническом полипозном риносинусите у детей с бронхиальной астмой.

   У каждого из этих коморбидных заболеваний есть четкие диагностические критерии, хотя со стороны врачей-специалистов имеет место их гиподиагностика.

   It has long been known that comorbid diseases such as chronic polypous rhinosinusitis and obesity adversely affect the pathophysiology of asthma, impair response to therapy and reduce the quality of life of patients. Identification and effective treatment of comorbidities will improve asthma control and reduce the frequency of exacerbations. There are more and more studies that indicate a close pathophysiological relationship with allergic diseases of eosinophilic esophagitis. According to the latest data in the development of allergic diseases (asthma, allergic rhinitis, atopic dermatitis, food allergy), chronic polypous rhinosinusitis, and eosinophilic esophagitis, the key is the T2 immune response (T2 inflammation) in both children and adults. Timely diagnosis of inflammatory states of T2 inflammation can help in choosing the optimal treatment for such patients. Here we describe the comorbid conditions that occur in an adolescent with controlled asthma and discuss the features of their clinical course.

   The purpose of this work is to raise the awareness of practitioners about comorbid diseases — eosinophilic esophagitis and chronic polypous rhinosinusitis in children with bronchial asthma.

   Each of these comorbid diseases has clear diagnostic criteria, although they are underdiagnosed by medical specialists.

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The authors declare that there are no conflicts of interest present.