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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">adair</journal-id><journal-title-group><journal-title xml:lang="ru">Аллергология и Иммунология в Педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Allergology and Immunology in Paediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2500-1175</issn><issn pub-type="epub">2712-7958</issn><publisher><publisher-name>Ассоциация детских аллергологов и иммунологов России</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.53529/2500-1175-2023-1-53-55</article-id><article-id custom-type="elpub" pub-id-type="custom">adair-39</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ И ПИСЬМА В РЕДАКЦИЮ. ПО СЛЕДАМ V ВСЕРОССИЙСКОГО СЪЕЗДА АССОЦИАЦИИ ДЕТСКИХ АЛЛЕРГОЛОГОВ И ИММУНОЛОГОВ РОССИИ (АДАИР)</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>COMMUNICATIONS AND CORRESPONDENCE. FOLLOWING THE V ALL-RUSSIAN CONGRESS OF THE ASSOCIATION OF PEDIATRIC ALLERGOLOGISTS AND IMMUNOLOGISTS OF RUSSIA (APAIR)</subject></subj-group></article-categories><title-group><article-title>Информативность лабораторных маркеров в оценке стадии фиброза печени у детей с аутоиммунным гепатитом первого типа</article-title><trans-title-group xml:lang="en"><trans-title>Informative value of laboratory markers in assessing the stage of liver fibrosis in children with type 1 autoimmune hepatitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Курбатова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurbatova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, г. Москва, Ломоносовский пр., д. 2, стр. 1</p></bio><bio xml:lang="en"><p>119991, Moscow, Lomonosovsky prospect, 2, building 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мовсисян</surname><given-names>Г. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Movsisyan</surname><given-names>G. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, г. Москва, Ломоносовский пр., д. 2, стр. 1</p></bio><bio xml:lang="en"><p>119991, Moscow, Lomonosovsky prospect, 2, building 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петричук</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrichuk</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, г. Москва, Ломоносовский пр., д. 2, стр. 1</p></bio><bio xml:lang="en"><p>119991, Moscow, Lomonosovsky prospect, 2, building 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Парахина</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Parakhina</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, г. Москва, Ломоносовский пр., д. 2, стр. 1</p></bio><bio xml:lang="en"><p>119991, Moscow, Lomonosovsky prospect, 2, building 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демьянов</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Demyanov</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, г. Москва, Ломоносовский пр., д. 2, стр. 1</p></bio><bio xml:lang="en"><p>119991, Moscow, Lomonosovsky prospect, 2, building 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Купцова</surname><given-names>Д. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuptsova</surname><given-names>D. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, г. Москва, Ломоносовский пр., д. 2, стр. 1</p></bio><bio xml:lang="en"><p>119991, Moscow, Lomonosovsky prospect, 2, building 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Радыгина</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Radygina</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, г. Москва, Ломоносовский пр., д. 2, стр. 1</p></bio><bio xml:lang="en"><p>119991, Moscow, Lomonosovsky prospect, 2, building 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семикина</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Semikina</surname><given-names>E. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, г. Москва, Ломоносовский пр., д. 2, стр. 1119991, г. Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>119991, Moscow, Lomonosovsky prospect, 2, building 1119991, Moscow, st. Trubetskaya, d. 8, building 2,</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потапов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Potapov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, г. Москва, Ломоносовский пр., д. 2, стр. 1119991, г. Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>119991, Moscow, Lomonosovsky prospect, 2, building 1119991, Moscow, st. Trubetskaya, d. 8, building 2,</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фрейдлин</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Freidlin</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, г. Москва, Ломоносовский пр., д. 2, стр. 1</p></bio><bio xml:lang="en"><p>119991, Moscow, Lomonosovsky prospect, 2, building 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГАУ «Национальный медицинский исследовательский центр здоровья детей» Министерства здравоохранения РФ<country>Россия</country></aff><aff xml:lang="en">National Medical Research Center for Children’s Health<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГАУ «Национальный медицинский исследовательский центр здоровья детей» Министерства здравоохранения РФ; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения РФ (Сеченовский университет)<country>Россия</country></aff><aff xml:lang="en">National Medical Research Center for Children’s Health; Sechenov First Moscow State Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>10</day><month>04</month><year>2023</year></pub-date><volume>0</volume><issue>1</issue><fpage>53</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Курбатова О.В., Мовсисян Г.Б., Петричук С.В., Парахина Д.В., Демьянов Д.С., Купцова Д.Г., Радыгина Т.В., Семикина Е.Л., Потапов А.С., Фрейдлин Е.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Курбатова О.В., Мовсисян Г.Б., Петричук С.В., Парахина Д.В., Демьянов Д.С., Купцова Д.Г., Радыгина Т.В., Семикина Е.Л., Потапов А.С., Фрейдлин Е.В.</copyright-holder><copyright-holder xml:lang="en">Kurbatova O.V., Movsisyan G.B., Petrichuk S.V., Parakhina D.V., Demyanov D.S., Kuptsova D.G., Radygina T.V., Semikina E.L., Potapov A.S., Freidlin E.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://adair.elpub.ru/jour/article/view/39">https://adair.elpub.ru/jour/article/view/39</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>аутоиммунный гепатит I типа</kwd><kwd>фиброз печени</kwd><kwd>Тreg</kwd><kwd>Th17</kwd><kwd>аутоиммунитет</kwd><kwd>проточная цитометрия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>type I autoimmune hepatitis</kwd><kwd>liver fibrosis</kwd><kwd>Treg</kwd><kwd>Th17</kwd><kwd>autoimmunity</kwd><kwd>flow cytometry</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Vuerich M, Wang N, Kalbasi A, Graham JJ, Longhi MS. Dysfunctional Immune Regulation in Autoimmune Hepatitis: From Pathogenesis to Novel Therapies. Front Immunol. 2021 Sep 28; 12: 746436. https://doi.org/10.3389/fimmu.2021.746436.</mixed-citation><mixed-citation xml:lang="en">Vuerich M, Wang N, Kalbasi A, Graham JJ, Longhi MS. Dysfunctional Immune Regulation in Autoimmune Hepatitis: From Pathogenesis to Novel Therapies. Front Immunol. 2021 Sep 28; 12: 746436. https://doi.org/10.3389/fimmu.2021.746436.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sirbe C, Simu G, Szabo I, Grama A, Pop TL. Pathogenesis of Autoimmune Hepatitis-Cellular and Molecular Mechanisms. Int J Mol Sci. 2021 Dec 17; 22 (24): 13578. https://doi.org/10.3390/ijms222413578.</mixed-citation><mixed-citation xml:lang="en">Sirbe C, Simu G, Szabo I, Grama A, Pop TL. Pathogenesis of Autoimmune Hepatitis-Cellular and Molecular Mechanisms. Int J Mol Sci. 2021 Dec 17; 22 (24): 13578. https://doi.org/10.3390/ijms222413578.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Patel AM, Liu YS, Davies SP, Brown RM, Kelly DA, Scheel-Toellner D, Reynolds GM, Stamataki Z. The Role of B Cells in Adult and Paediatric Liver Injury. Front Immunol. 2021 Sep 23; 12: 729143. https://doi.org/10.3389/fimmu.2021.729143.</mixed-citation><mixed-citation xml:lang="en">Patel AM, Liu YS, Davies SP, Brown RM, Kelly DA, Scheel-Toellner D, Reynolds GM, Stamataki Z. The Role of B Cells in Adult and Paediatric Liver Injury. Front Immunol. 2021 Sep 23; 12: 729143. https://doi.org/10.3389/fimmu.2021.729143.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y, Yan L, Wang R, Wang Q, You Z, Li B, Zhang J, Huang B, Chen Y, Li Y, Lian M, Tang R, Qiu D, Gershwin ME, Xiao X, Miao Q, Ma X. Serum Immunoglobulin G Levels Predict Biochemical and Histological Remission of Autoimmune Hepatitis Type 1: A Single-Center Experience and Literature Review. Clin Rev Allergy Immunol. 2022 Apr; 62 (2): 292–300. https://doi.org/10.1007/s12016-021-08833-w.</mixed-citation><mixed-citation xml:lang="en">Li Y, Yan L, Wang R, Wang Q, You Z, Li B, Zhang J, Huang B, Chen Y, Li Y, Lian M, Tang R, Qiu D, Gershwin ME, Xiao X, Miao Q, Ma X. Serum Immunoglobulin G Levels Predict Biochemical and Histological Remission of Autoimmune Hepatitis Type 1: A Single-Center Experience and Literature Review. Clin Rev Allergy Immunol. 2022 Apr; 62 (2): 292–300. https://doi.org/10.1007/s12016-021-08833-w.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Wang P, Wang Y, Liu H, Han X, Yi Y, Wang X, Li X. Role of triglycerides as a predictor of autoimmune hepatitis with cirrhosis. Lipids Health Dis. 2022 Oct 25; 21 (1): 108. https://doi.org/10.1186/s12944-022-01716-9.</mixed-citation><mixed-citation xml:lang="en">Wang P, Wang Y, Liu H, Han X, Yi Y, Wang X, Li X. Role of triglycerides as a predictor of autoimmune hepatitis with cirrhosis. Lipids Health Dis. 2022 Oct 25; 21 (1): 108. https://doi.org/10.1186/s12944-022-01716-9.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Biewenga M, Verhelst X, Baven-Pronk M, Putter H, van den Berg A, Colle I, Schouten J, Sermon F, Van Steenkiste C, van Vlierberghe H, van der Meer A, van Hoek B; Dutch Autoimmune Hepatitis Study Group. Aminotransferases During Treatment Predict Long-Term Survival in Patients With Autoimmune Hepatitis Type 1: A Landmark Analysis. Clin Gastroenterol Hepatol. 2022 Aug; 20 (8): 1776–1783.e4. https://doi.org/10.1016/j.cgh.2021.05.024.</mixed-citation><mixed-citation xml:lang="en">Biewenga M, Verhelst X, Baven-Pronk M, Putter H, van den Berg A, Colle I, Schouten J, Sermon F, Van Steenkiste C, van Vlierberghe H, van der Meer A, van Hoek B; Dutch Autoimmune Hepatitis Study Group. Aminotransferases During Treatment Predict Long-Term Survival in Patients With Autoimmune Hepatitis Type 1: A Landmark Analysis. Clin Gastroenterol Hepatol. 2022 Aug; 20 (8): 1776–1783.e4. https://doi.org/10.1016/j.cgh.2021.05.024.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Pan Y, Yang K, Sun B, Chen J, Tian P. Application of alkaline phosphatase to platelet ratio as a novel noninvasive index predicts liver fibrosis in patients with chronic hepatitis B. Exp Ther Med. 2022 Aug 9; 24 (4): 619. https://doi.org/10.3892/etm.2022.11556.</mixed-citation><mixed-citation xml:lang="en">Pan Y, Yang K, Sun B, Chen J, Tian P. Application of alkaline phosphatase to platelet ratio as a novel noninvasive index predicts liver fibrosis in patients with chronic hepatitis B. Exp Ther Med. 2022 Aug 9; 24 (4): 619. https://doi.org/10.3892/etm.2022.11556.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Harrington C, Krishnan S, Mack CL, Cravedi P, Assis DN, Levitsky J. Noninvasive biomarkers for the diagnosis and management of autoimmune hepatitis. Hepatology. 2022 Dec; 76 (6): 1862–1879. https://doi.org/10.1002/hep.32591.</mixed-citation><mixed-citation xml:lang="en">Harrington C, Krishnan S, Mack CL, Cravedi P, Assis DN, Levitsky J. Noninvasive biomarkers for the diagnosis and management of autoimmune hepatitis. Hepatology. 2022 Dec; 76 (6): 1862–1879. https://doi.org/10.1002/hep.32591.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Кулебина ЕА, Сурков АН, Куликов КА, Потапов АС, Бессонов ЕЕ. Валидация показателей транзиентной эластографии для оценки стадии фиброза печени у детей. Лечащий Врач. 2020; 8: 57–60. https://doi.org/10.26295/OS.2020.26.84.00.</mixed-citation><mixed-citation xml:lang="en">Kulebina EA, Surkov AN, Kulikov KA, Potapov AS, Bessonov EE. Validaciya pokazatelej tranzientnoj elastografii dlya ocenki stadii fibroza pecheni u detej. Lechashchij Vrach. 2020; 8: 57–60. (In Russ.) https://doi.org/10.26295/OS.2020.26.84.00.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
