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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">adair</journal-id><journal-title-group><journal-title xml:lang="ru">Аллергология и Иммунология в Педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Allergology and Immunology in Paediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2500-1175</issn><issn pub-type="epub">2712-7958</issn><publisher><publisher-name>Ассоциация детских аллергологов и иммунологов России</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.53529/2500-1175-2025-4-64-73</article-id><article-id custom-type="elpub" pub-id-type="custom">adair-232</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MEDICAL CASES</subject></subj-group></article-categories><title-group><article-title>Перекрестная сенсибилизация к семейству тропомиозинов: клинический случай анафилаксии у ребенка</article-title><trans-title-group xml:lang="en"><trans-title>Cross-sensitization to the tropomyosin family: a clinical case of anaphylaxis in a child</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1806-0787</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стежкина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Stezhkina</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Стежкина Елена Викторовна — к. м. н., доцент кафедры факультетской и поликлинической педиатрии с курсом педиатрии ФДПО Федерального государственного бюджетного образовательного учреждения высшего образования «Рязанский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации; врач аллерголог-иммунолог, педиатр высшей категории, член правления АДАИР</p><p>г. Рязань, 390026, ул. Высоковольтная, 9</p><p>г. Рязань, 390048, ул. Новоселов, 32А</p></bio><bio xml:lang="en"><p>Elena Viktorovna Stezhkina — Cand. Sci., Associate Professor, Department of Faculty and Polyclinic Pediatrics with a course in pediatrics, Ryazan State Medical University Russia, allergologist-immunologist, pediatrician of the highest category, ADAIR board member</p><p>Ryazan, 390026, Vysokovoltnaya Street, 9</p><p>Ryazan, 390048, Novoselov Street, 32A</p></bio><email xlink:type="simple">polus1972@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-2051-5778</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чеботарева</surname><given-names>Д. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Chebotareva</surname><given-names>D. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чеботарева Дарья Олеговна — ординатор Федерального государственного бюджетного образовательного учреждения высшего образования «Рязанский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации</p><p>г. Рязань, 390026, ул. Высоковольтная, 9</p></bio><bio xml:lang="en"><p>Darya Olegovna Chebotareva — resident at the Federal State Budgetary Educational Institution of Higher Education ‘Ryazan State Medical University named after Academician I. P. Pavlov’ of the Ministry of Health of the Russian Federation</p><p>Ryazan, 390026, Vysokovoltnaya Street, 9</p></bio><email xlink:type="simple">chebotareva_do@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное государственное бюджетное образовательное учреждение высшего образования «Рязанский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации;&#13;
Государственное бюджетное учреждение Рязанской области «Городская детская поликлиника N°7»<country>Россия</country></aff><aff xml:lang="en">Federal State Budgetary Educational Institution of Higher Education ‘Ryazan State Medical University named after Academician I. P. Pavlov’ of the Ministry of Health of the Russian Federation;&#13;
State Budgetary Institution of the Ryazan Region ‘City Children’s Polyclinic No. 7’<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральное государственное бюджетное образовательное учреждение высшего образования «Рязанский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Federal State Budgetary Educational Institution of Higher Education ‘Ryazan State Medical University named after Academician I. P. Pavlov’ of the Ministry of Health of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>28</day><month>01</month><year>2026</year></pub-date><volume>0</volume><issue>4</issue><fpage>64</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Стежкина Е.В., Чеботарева Д.О., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Стежкина Е.В., Чеботарева Д.О.</copyright-holder><copyright-holder xml:lang="en">Stezhkina E.V., Chebotareva D.O.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://adair.elpub.ru/jour/article/view/232">https://adair.elpub.ru/jour/article/view/232</self-uri><abstract><p>Актуальность. Распространенность аллергии на ракообразных оценивается примерно в 0,5–2,5 % среди населения и зависит от возраста пациента, степени потребления морепродуктов в питании, географических регионов, а также метода диагностики. В большинстве случаев в клинике фиксируются тяжелые анафилактические реакции.Материалы и методы. Работа основана на анализе медицинской документации и личной курации пациента 12 лет с полисенсибилизацией и повторными эпизодами анафилаксии.Результат. В статье описан клинический случай перекрестной сенсибилизации между ракообразными и клещами домашней пыли у ребенка с коморбидной полиаллергией. Мальчик 12 лет с отягощенным аллергологическим анамнезом. Старт атопического марша с тяжелого атопического дерматита, связанный с сенсибилизацией к белкам коровьего молока, с рецидивирующими ангиоотеками и анафилаксией. С 2 лет — персистирующий аллергический ринит и бронхообструктивный синдром при сенсибилизации к клещам домашней пыли. Последний эпизод анафилаксии возник в ответ на употребление вареной креветки. Развитие клинических симптомов в ответ на употребление ракообразных у пациентов с первичной сенсибилизацией к клещам домашней пыли опосредовано перекрестной реактивностью аллергенов семейства тропомиозинов.Заключение. Оценка перекрестной сенсибилизации имеет решающее значение для правильного информирования пациента во избежание новых эпизодов аллергических реакций. Именно поэтому пациентам с коморбидной аллергией следует проводить компонентную аллергодиагностику.</p></abstract><trans-abstract xml:lang="en"><p>Relevance. The prevalence of shellfish allergy is estimated to be approximately 0.5–2.5 % among the population and varies depending on the patient’s age, the degree of seafood consumption in their diet, geographical regions, and the method of diagnosis. In most cases, severe anaphylactic reactions are recorded in clinical settings.Materials and methods. The study is based on an analysis of medical records and personal supervision of a 12-year-old patient with polysensitization and recurrent episodes of anaphylaxis.Results. The article describes a clinical case of cross-sensitization between shellfish and house dust mites in a child with comorbid polyallergy. A 12-year-old boy with a complicated allergic history. The onset of atopic march began with severe atopic dermatitis associated with sensitization to cow’s milk proteins, accompanied by recurrent angioedema and anaphylaxis. From the age of 2, he experienced persistent allergic rhinitis and bronchial obstruction syndrome due to sensitization to house dust mites. The most recent episode of anaphylaxis occurred in response to the consumption of cooked shrimp. The development of clinical symptoms in response to shellfish consumption in patients with primary sensitization to house dust mites is mediated by cross-reactivity of allergens from the tropomyosin family.Conclusion. Assessment of cross-sensitization is crucial to properly inform the patient to avoid new episodes of allergic reactions. For this reason, patients with comorbid allergies should undergo component allergodiagnosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пищевая анафилаксия</kwd><kwd>перекрестная сенсибилизация</kwd><kwd>клещи домашней пыли</kwd><kwd>ракообразные</kwd><kwd>креветки</kwd><kwd>тропомиозины</kwd><kwd>атопический марш</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>food anaphylaxis</kwd><kwd>cross-sensitization</kwd><kwd>house dust mites</kwd><kwd>crustaceans</kwd><kwd>shrimps</kwd><kwd>tropomyosins</kwd><kwd>atopic march</kwd><kwd>children.</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Buono E.V., Giannì G., Scavone S., Esposito S., Caffarelli C. 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