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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">adair</journal-id><journal-title-group><journal-title xml:lang="ru">Аллергология и Иммунология в Педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Allergology and Immunology in Paediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2500-1175</issn><issn pub-type="epub">2712-7958</issn><publisher><publisher-name>Ассоциация детских аллергологов и иммунологов России</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24412/2500-1175-2021-2-4-10</article-id><article-id custom-type="elpub" pub-id-type="custom">adair-20</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Современный взгляд на проблему распространенности аллергических заболеваний у детей</article-title><trans-title-group xml:lang="en"><trans-title>The issue of the allergic diseases prevalence among children: a current review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2014-4709</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьмичева</surname><given-names>К. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzmicheva</surname><given-names>K. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кузьмичева Ксения Павловна, аспирант кафедры детских болезней лечебного факультета с курсом иммунологии и аллергологии</p><p>625023, г. Тюмень, ул. Одесская, д. 54 </p></bio><bio xml:lang="en"><p>Kseniya P. Kuzmicheva, postgraduate student at the Children' Diseases with course of immunology and allergology Department of the Faculty of General Medicine</p><p>Odesskaya Str., 54, 625023, Tyumen, Russia </p></bio><email xlink:type="simple">ksyu-sidorova@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малинина</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Malinina</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Tyumen</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рычкова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Richkova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Tyumen</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО Тюменский ГМУ Минздрава России</institution></aff><aff xml:lang="en"><institution>Tyumen State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>21</day><month>03</month><year>2023</year></pub-date><volume>0</volume><issue>2</issue><fpage>4</fpage><lpage>10</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кузьмичева К.П., Малинина Е.И., Рычкова О.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Кузьмичева К.П., Малинина Е.И., Рычкова О.А.</copyright-holder><copyright-holder xml:lang="en">Kuzmicheva K.P., Malinina E.I., Richkova O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://adair.elpub.ru/jour/article/view/20">https://adair.elpub.ru/jour/article/view/20</self-uri><abstract><p>Проблема роста распространенности аллергических заболеваний остается крайне актуальной на протяжении последних десятилетий, вследствие того, что данные официальной статистики не отражают истинного положения дел в отношении частоты встречаемости разных аллергических заболеваний. Так, только от бронхиальной астмы (БА) страдает по всему миру более 339 миллионов человек, хотя истинные значения могут быть в несколько раз выше. В настоящее время оценить распространенность БА и других аллергических заболеваний, в частности атопического дерматита (АтД), аллергического ринита (АР), позволяют глобальные популяционные исследования, такие как ISAAC (International Study of Asthma and Allergies in Childhood) и GAN (Global Asthma Network). Трудности в эпидемиологическом надзоре, диагностике, лечении и профилактике данных нозологий испытывают большинство стран мира, а в особенности развивающиеся страны, где имеются проблемы с доступностью терапии. Благодаря функционированию программы GAN формируются терапевтические рекомендации в целях снижения глобального бремени аллергопатологии. Цель данной статьи — представить результаты эпидемиологических исследований по распространенности аллергических заболеваний, а также факторы, влияющие на данные показатели в детской популяции.</p></abstract><trans-abstract xml:lang="en"><p>The problem of upgrowth the allergic diseases prevalence remain extremely relevant over the recent decade, due to the fact that official statistics do not reflect the true state of affairs regarding the frequency of various allergic diseases. Thus, more than 339 million people suffer from bronchial asthma (BA) worldwide, although the true values may be several times higher. Currently, global population studies, such as the International Study of Asthma and Allergies in Childhood — ISAAC, and the Global Asthma Network — GAN, allow us to assess the prevalence of allergic diseases, in particular atopic dermatitis (AtD) and allergic rhinitis (AR). Difficulties in epidemiological surveillance, diagnosis, treatment and prevention of these nosologies are experienced by most countries of the world, and especially developing countries where there are problems with the availability of therapy. Owing to the GAN program, therapeutic recommendations are formed in order to reduce the global burden of allergopathology. The purpose of this article is to present the results of epidemiological studies on the prevalence of allergic diseases, as well as factors affecting these indicators in the child population.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бронхиальная астма</kwd><kwd>атопический дерматит</kwd><kwd>аллергический ринит</kwd><kwd>распространенность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bronchial asthma</kwd><kwd>atopic dermatitis</kwd><kwd>allergic rhinitis</kwd><kwd>prevalence</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Platts-Mills T.A. How environment affects patients with allergic disease: indoor allergens and asthma //Ann Allergy. 1994; 72(4): p. 381. doi: 10.1016/j.jaci.2015.03.048</mixed-citation><mixed-citation xml:lang="en">Platts-Mills T.A. How environment affects patients with allergic disease: indoor allergens and asthma //Ann Allergy. 1994; 72(4): p. 381. doi: 10.1016/j.jaci.2015.03.048</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Кубанова А.А.,. Лесная И.Н.,. Мелехина Л.Е. и др. Анализ эпидемиологической ситуации и динамики заболеваемости инфекциями, передаваемыми половым путем, и дерматозами на территории Российской Федерации //Вестник дерматологии и венерологии. 2010; 5: с. 4–21. doi:10.25208/vdv913</mixed-citation><mixed-citation xml:lang="en">Kubanova A.A., Lesnaya I.N., Melekhina L.Ye. i dr. Analysis of the epidemiological situation and dynamics of STD and dermatosis morbility in the territory of the Russian Federation //Vestnik dermatologii i venerologii. 2010; 5: s. 4–21. (In Russ). doi:10.25208/vdv913</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">G.A. Network. The Global Asthma Report Asthma affects. 2018: p. 12–22.</mixed-citation><mixed-citation xml:lang="en">G.A. Network. The Global Asthma Report Asthma affects. 2018: p. 12–22.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bégin P., Nadeau K.C. Epigenetic regulation of asthma and allergic disease //Allergy, Asthma and Clinical Immunilogy. 2014: 1–12. doi: 10.1186/1710-1492-10-27</mixed-citation><mixed-citation xml:lang="en">Bégin P., Nadeau K.C. Epigenetic regulation of asthma and allergic disease //Allergy, Asthma and Clinical Immunilogy. 2014: 1–12. doi: 10.1186/1710-1492-10-27</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Strachan D.P. Hay fever, hygiene, and household size //Br Medj. 1989; 99: p. 1259–1260. doi: 10.1136/bmj.299.6710.1259</mixed-citation><mixed-citation xml:lang="en">Strachan D.P. Hay fever, hygiene, and household size //Br Medj. 1989; 99: p. 1259–1260. doi: 10.1136/bmj.299.6710.1259</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hesselmar B., Sjöberg F., Saalman R. et al. Pacifier cleaning practices and risk of allergy development //Pediatrics. 2013; 131(6): p. 1829–1837. doi: 10.1542/peds.2012-3345</mixed-citation><mixed-citation xml:lang="en">Hesselmar B., Sjöberg F., Saalman R. et al. Pacifier cleaning practices and risk of allergy development //Pediatrics. 2013; 131(6): p. 1829–1837. doi: 10.1542/peds.2012-3345</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Arrieta M.C,. Stiemsma L.T., Dimitriu P.A. Early infancy microbial and metabolic alterations affect risk of childhood asthma //Sci Transl Med. 2015; 7(307): ra152. doi: 10.1126/scitranslmed.aab2271</mixed-citation><mixed-citation xml:lang="en">Arrieta M.C,. Stiemsma L.T., Dimitriu P.A. Early infancy microbial and metabolic alterations affect risk of childhood asthma //Sci Transl Med. 2015; 7(307): ra152. doi: 10.1126/scitranslmed.aab2271</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kobayashi Y., Bossley C., Gupta A. et al. Passive Smoking Impairs Histone //Chest. 2014; 2(February): p. 305– 312. doi: 10.1378/chest.13-0835</mixed-citation><mixed-citation xml:lang="en">Kobayashi Y., Bossley C., Gupta A. et al. Passive Smoking Impairs Histone //Chest. 2014; 2(February): p. 305– 312. doi: 10.1378/chest.13-0835</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. The Lancet (London, England). 1998; 351: p. 1225–1232. doi: doi.org/10.1016/S0140-6736(97)07302-9</mixed-citation><mixed-citation xml:lang="en">Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. The Lancet (London, England). 1998; 351: p. 1225–1232. doi: doi.org/10.1016/S0140-6736(97)07302-9</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Wang D., Xiao W., Ma D. et al. Cross-sectional epidemiological survey of asthma in Jinan, China //Respirology. 2013; 18: p. 313–322. doi: 10.1111/resp.12005</mixed-citation><mixed-citation xml:lang="en">Wang D., Xiao W., Ma D. et al. Cross-sectional epidemiological survey of asthma in Jinan, China //Respirology. 2013; 18: p. 313–322. doi: 10.1111/resp.12005</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Камалтынова Е.М., Деев И.А., Белоногова Е.Г. Сравнительная эпидемиологическая характеристика бронхиальной астмы по данным программы «Международное исследование астмы и аллергии у детей» (International Study of Asthma and Allergy in Childhood) //Бюллетень Сибирской Медицины. 2009, 8(4): c. 92–97. . doi:10.20538/1682-0363-2009-4-92-97</mixed-citation><mixed-citation xml:lang="en">Kamaltynova E.M., Deev I.A., Belonogova E.G. Sravnitel'naya epidemiologicheskaya harakteristika bronhial'noj astmy po dannym programmy «Mezhdunarodnoe issledovanie astmy i allergii u detej» (International Study of Asthma and Allergy in Childhood) //Byulleten' Sibirskoj Mediciny. 2009, 8(4): c.92–97. (In Russ.)]. doi:10.20538/1682-0363-2009-4-92-97</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Зайцева С.В., Зайцева О.В., Локшина Э.Э., Застрожина А.К., Муртазаева О.А. Тяжeлая бронхиальная астма у детей //Аллергология и иммунология в педиатрии. 2019; 58(3): c. 4–14. doi: 10.24411/2500-1175-2019-00011</mixed-citation><mixed-citation xml:lang="en">Zajceva S.V., Zajceva O.V., Lokshina E.E., Zastrozhina A.K., Murtazaeva O.A. Tyazhelaya bronhial'naya astma u detej //Allergologiya i immunologiya v pediatrii. 2019; 58(3): c. 4–14.(In Russ). doi: 10.24411/2500-1175-2019-00011</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bousquet J., Mantzouranis E., Crus A.A. et al. Workshop summary uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma //Allergy Clin Immunol. 2010; 126(5): p. 926–938. doi: 10.1016/j.jaci.2010.07.019</mixed-citation><mixed-citation xml:lang="en">Bousquet J., Mantzouranis E., Crus A.A. et al. Workshop summary uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma //Allergy Clin Immunol. 2010; 126(5): p. 926–938. doi: 10.1016/j.jaci.2010.07.019</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">G.A. Network. The Global Asthma Report Asthma may affect as many as. 2014.</mixed-citation><mixed-citation xml:lang="en">G.A. Network. The Global Asthma Report Asthma may affect as many as. 2014.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Bu. The Lancet. 2015: 386(9995): p. 743–800. doi: https://doi.org/10.1016/S01406736(15)60692-4</mixed-citation><mixed-citation xml:lang="en">Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Bu. The Lancet. 2015: 386(9995): p. 743–800. doi: https://doi.org/10.1016/S01406736(15)60692-4</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Намазова-Баранова Л.С., Баранов А.А., Кубанова А.А. и др. Атопический дерматит у детей: современные клинические рекомендации по диагностике и терапии //Вопросы современной педиатрии. 2016; 15(3): c. 279–294.doi.org/10.15690/vsp.v15i3.1566</mixed-citation><mixed-citation xml:lang="en">Namazova-Baranova L.S., Baranov A.A., Kubanova A.A. i dr. Atopicheskij dermatit u detej: sovremennye klinicheskie rekomendacii po diagnostike i terapii //Voprosy sovremennoj pediatrii. 2016; 15(3): c. 279– 294.(In Russ.). doi.org/10.15690/vsp.v15i3.1566</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Katelaris C.H., Lee B.W., Potter P.C. et al. Prevalence and diversity rhinitis in regions of the world beyond Europe and North Americ //Clin Exp Allergy. 2012; 42(2): p. 186–207. doi: 10.1111/j.1365-2222.2011.03891.x</mixed-citation><mixed-citation xml:lang="en">Katelaris C.H., Lee B.W., Potter P.C. et al. Prevalence and diversity rhinitis in regions of the world beyond Europe and North Americ //Clin Exp Allergy. 2012; 42(2): p. 186–207. doi: 10.1111/j.1365-2222.2011.03891.x</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Katelaris С., Lai K.W., Rhee C.S. et al. Nasal allergies in the Asia-Pacific population: results from the allergies in Asia-Pacific survey //Am J Rhinol Allergy. 2011; 25(5): p. 3–15. doi: 10.2500/ajra.2011.25.3674</mixed-citation><mixed-citation xml:lang="en">Katelaris С., Lai K.W., Rhee C.S. et al. Nasal allergies in the Asia-Pacific population: results from the allergies in Asia-Pacific survey //Am J Rhinol Allergy. 2011; 25(5): p. 3–15. doi: 10.2500/ajra.2011.25.3674</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Brain M. Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis //J Invest Dermatol. 2007; 127(3): p. 724–726. doi: 10.1038/sj.jid.5700630</mixed-citation><mixed-citation xml:lang="en">Brain M. Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis //J Invest Dermatol. 2007; 127(3): p. 724–726. doi: 10.1038/sj.jid.5700630</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Mallol J., Crane J., Mutius E. et al. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three: a global synthesis //Allergol Immunopathologia. 2013; 41(2): p. 73–85. doi: 10.1016/j.aller.2012.03.001</mixed-citation><mixed-citation xml:lang="en">Mallol J., Crane J., Mutius E. et al. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three: a global synthesis //Allergol Immunopathologia. 2013; 41(2): p. 73–85. doi: 10.1016/j.aller.2012.03.001</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Альбанова В.И., Пампура А.Н. Атопический дерматит. — Москва: ГЭОТАР-Медиа, 2016. C. 128.</mixed-citation><mixed-citation xml:lang="en">Al'banova V.I., Pampura A.N. Atopicheskii dermatit. — Moskva: GEHOTAR-Media, 2016. S. 128. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Somanunt S., Chinratanapisit S., Pacharn P. et al. The natural history of atopic dermatitis and its association with Atopic March //Asian Pacific J Allergy Immunol. 2017; 35(3): p. 137–143. doi: 10.12932/AP0825</mixed-citation><mixed-citation xml:lang="en">Somanunt S., Chinratanapisit S., Pacharn P. et al. The natural history of atopic dermatitis and its association with Atopic March //Asian Pacific J Allergy Immunol. 2017; 35(3): p. 137–143. doi: 10.12932/AP0825</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Eller E., Kjaer H.F., Host A. et al. Food allergy and food sensitization in early childhood: results from the DARC cohort //Allergy. 2009; 64(7): p. 1023–1029. doi: 10.1111/j.1398-9995.2009.01952.x</mixed-citation><mixed-citation xml:lang="en">Eller E., Kjaer H.F., Host A. et al. Food allergy and food sensitization in early childhood: results from the DARC cohort //Allergy. 2009; 64(7): p. 1023–1029. doi: 10.1111/j.1398-9995.2009.01952.x</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kvenshagen B., Jacobsen M. Atopic dermatitis in premature and term children //Arch Dis Child. 2009; 94: p. 202– 225. doi: 10.1136/adc.2008.142869</mixed-citation><mixed-citation xml:lang="en">Kvenshagen B., Jacobsen M. Atopic dermatitis in premature and term children //Arch Dis Child. 2009; 94: p. 202– 225. doi: 10.1136/adc.2008.142869</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Shaw T.E., Currie G.P., Koudelka C.W. et al. Eczema prevalence in the United States: data from the 2003 //Natl Surv Child Heal J Invest Dermatol. 2011; 131(1): p. 67–73. doi: 10.1038/jid.2010.251</mixed-citation><mixed-citation xml:lang="en">Shaw T.E., Currie G.P., Koudelka C.W. et al. Eczema prevalence in the United States: data from the 2003 //Natl Surv Child Heal J Invest Dermatol. 2011; 131(1): p. 67–73. doi: 10.1038/jid.2010.251</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Mortz C.G., Andersen K.E., Dellgren C. et al. Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities //Allergy. 2015; 70(7): p. 836–845. doi: 10.1111/all.12619</mixed-citation><mixed-citation xml:lang="en">Mortz C.G., Andersen K.E., Dellgren C. et al. Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities //Allergy. 2015; 70(7): p. 836–845. doi: 10.1111/all.12619</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Liu F., Killian J.K., Yang M. et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. 2010; (May): p. 3650–3664. doi: 10.1038/onc.2010.129</mixed-citation><mixed-citation xml:lang="en">Liu F., Killian J.K., Yang M. et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. 2010; (May): p. 3650–3664. doi: 10.1038/onc.2010.129</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Belanger K., Gent J.F., Triche E.W. et al. Association of Indoor Nitrogen Dioxide Exposure with Respiratory Symptoms in Children with Asthma //Am J Respir Crit Care Med. 2006; 173: p. 297–303. doi: 10.1164/rccm.200408-1123OC</mixed-citation><mixed-citation xml:lang="en">Belanger K., Gent J.F., Triche E.W. et al. Association of Indoor Nitrogen Dioxide Exposure with Respiratory Symptoms in Children with Asthma //Am J Respir Crit Care Med. 2006; 173: p. 297–303. doi: 10.1164/rccm.200408-1123OC</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Gascon M., Casas M., Morales E. et al. Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy //J Allergy Clin Immunol. 2015 Feb; 135(2): p. 370–378. doi: 10.1016/j.jaci.2014.09.030</mixed-citation><mixed-citation xml:lang="en">Gascon M., Casas M., Morales E. et al. Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy //J Allergy Clin Immunol. 2015 Feb; 135(2): p. 370–378. doi: 10.1016/j.jaci.2014.09.030</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Hanrahan J.P., Tager I.B., Segal M.R. et al.The effect of maternal smoking during pregnancy on early infant lung function //Am Rev Respir Dis.1992; 145(5): p. 1129–1135. doi: 10.1164/ajrccm/145.5.1129</mixed-citation><mixed-citation xml:lang="en">Hanrahan J.P., Tager I.B., Segal M.R. et al.The effect of maternal smoking during pregnancy on early infant lung function //Am Rev Respir Dis.1992; 145(5): p. 1129–1135. doi: 10.1164/ajrccm/145.5.1129</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Braun-Fahrländer C., Riedler J., Herz U. et al. Environmental exposure to endotoxin and its relation to asthma in school-age children //N Engl J Med. 2002; 347(12): p. 869–877. doi: 10.1056/NEJMoa020057</mixed-citation><mixed-citation xml:lang="en">Braun-Fahrländer C., Riedler J., Herz U. et al. Environmental exposure to endotoxin and its relation to asthma in school-age children //N Engl J Med. 2002; 347(12): p. 869–877. doi: 10.1056/NEJMoa020057</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Fall T., Lundholm C., Örtqvist A.K. et al. Early exposure to dogs and farm animals and the risk of childhood asthma //JAMA Pediatr. 2015; 169(11): p. 169:e153219. doi: 10.1001/jamapediatrics.2015.3219</mixed-citation><mixed-citation xml:lang="en">Fall T., Lundholm C., Örtqvist A.K. et al. Early exposure to dogs and farm animals and the risk of childhood asthma //JAMA Pediatr. 2015; 169(11): p. 169:e153219. doi: 10.1001/jamapediatrics.2015.3219</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Yemaneberhan H., Bekele Z., Venn A. et al. Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia. The Lancet. 1997; 350(9071): p. 85–90. doi: 10.1016/S0140-6736(97)01151-3</mixed-citation><mixed-citation xml:lang="en">Yemaneberhan H., Bekele Z., Venn A. et al. Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia. The Lancet. 1997; 350(9071): p. 85–90. doi: 10.1016/S0140-6736(97)01151-3</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Perzanowski M.S., Ng’ang’a L.W., Carter M.C. et al. Atopy, asthma, and antibodies to Ascaris among rural and urban children in Kenya //J Pediatr. 2002; 140(5): p. 582–588. doi: 10.1067/mpd.2002.122937</mixed-citation><mixed-citation xml:lang="en">Perzanowski M.S., Ng’ang’a L.W., Carter M.C. et al. Atopy, asthma, and antibodies to Ascaris among rural and urban children in Kenya //J Pediatr. 2002; 140(5): p. 582–588. doi: 10.1067/mpd.2002.122937</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Duchén K., Casas R., Fagerås-Böttcher M. et al. Human milk polyunsaturated long-chain fatty acids and secretory immunoglobulin A antibodies and early childhood allergy //Pediatr Allergy Immunol. 2000; 11(1): p. 29–39. doi: 10.1034/j.1399-3038.2000.00052.x</mixed-citation><mixed-citation xml:lang="en">Duchén K., Casas R., Fagerås-Böttcher M. et al. Human milk polyunsaturated long-chain fatty acids and secretory immunoglobulin A antibodies and early childhood allergy //Pediatr Allergy Immunol. 2000; 11(1): p. 29–39. doi: 10.1034/j.1399-3038.2000.00052.x</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Dennison B., Erb T., Jenkins P. Television Viewing and Television in Bedroom Associated With Overweight Risk Among Low-Income Preschool Children //Pediatrics. 2002; 109(6): p. 1028–1035. doi: 10.1542/peds.109.6.1028</mixed-citation><mixed-citation xml:lang="en">Dennison B., Erb T., Jenkins P. Television Viewing and Television in Bedroom Associated With Overweight Risk Among Low-Income Preschool Children //Pediatrics. 2002; 109(6): p. 1028–1035. doi: 10.1542/peds.109.6.1028</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Platts-Mills T., Sporik R., Chapman M. et al. The role of domestic allergens. 1999; 206: p. 173–185. doi: 10.1002/9780470515334.ch11</mixed-citation><mixed-citation xml:lang="en">Platts-Mills T., Sporik R., Chapman M. et al. The role of domestic allergens. 1999; 206: p. 173–185. doi: 10.1002/9780470515334.ch11</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Beasley R., Clayton T., Crane J. et al. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6–7 years: analysis from Phase Three of the ISAAC programme //The Lancet. 2008; 372(9643): p. 1039–1048). doi: 10.26444/aaem/86336</mixed-citation><mixed-citation xml:lang="en">Beasley R., Clayton T., Crane J. et al. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6–7 years: analysis from Phase Three of the ISAAC programme //The Lancet. 2008; 372(9643): p. 1039–1048). doi: 10.26444/aaem/86336</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Beasley R.W., Clayton T.O., Crane J. et al. Acetaminophen Use and Risk of Asthma , Rhinoconjunctivitis , and Eczema in Adolescents International Study of Asthma and Allergies in Childhood Phase Three //American Journal of Respiratory and Critical Care Medicine. 2011; 183(2): p. 171–178. doi: 10.1164/rccm.201005-0757OC</mixed-citation><mixed-citation xml:lang="en">Beasley R.W., Clayton T.O., Crane J. et al. Acetaminophen Use and Risk of Asthma , Rhinoconjunctivitis , and Eczema in Adolescents International Study of Asthma and Allergies in Childhood Phase Three //American Journal of Respiratory and Critical Care Medicine. 2011; 183(2): p. 171–178. doi: 10.1164/rccm.201005-0757OC</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Wright R.J. Asthma and lower airway disease Maternal asthma severity and control during pregnancy and risk of offspring asthma //J Allergy Clin Immunol. 2018; 141(3): p. 886–892. doi: 10.1016/j.jaci.2017.05.016</mixed-citation><mixed-citation xml:lang="en">Wright R.J. Asthma and lower airway disease Maternal asthma severity and control during pregnancy and risk of offspring asthma //J Allergy Clin Immunol. 2018; 141(3): p. 886–892. doi: 10.1016/j.jaci.2017.05.016</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Sevelsted A., Stokholm J., Bisgaard H. Risk of Asthma from Cesarean Delivery Depends on Membrane Rupture //J Pediatr. 2016; 171: p. 38–42.e4. doi: 10.1016/j.jpeds.2015.12.066</mixed-citation><mixed-citation xml:lang="en">Sevelsted A., Stokholm J., Bisgaard H. Risk of Asthma from Cesarean Delivery Depends on Membrane Rupture //J Pediatr. 2016; 171: p. 38–42.e4. doi: 10.1016/j.jpeds.2015.12.066</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kramer M.S., Matush L., Vanilovich I. et al. Effect of prolonged and exclusive breast feeding on risk of allergy and asthma: cluster randomised trial //BMJ. 2007; 335: p. 815. doi: 10.1136/bmj.39304.464016.AE</mixed-citation><mixed-citation xml:lang="en">Kramer M.S., Matush L., Vanilovich I. et al. Effect of prolonged and exclusive breast feeding on risk of allergy and asthma: cluster randomised trial //BMJ. 2007; 335: p. 815. doi: 10.1136/bmj.39304.464016.AE</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Egan K.B., Ettinger A.S., Bracken M.B. Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies //BMC Pediatr. 2013; 13: p. 121. doi: 10.1186/1471-2431-13-121</mixed-citation><mixed-citation xml:lang="en">Egan K.B., Ettinger A.S., Bracken M.B. Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies //BMC Pediatr. 2013; 13: p. 121. doi: 10.1186/1471-2431-13-121</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Naldi L., Parazzini F., Gallus S. et al. Prevalence of Atopic Dermatitis in Italian Schoolchildren: Factors Affecting its Variation //Acta Derm Venereol. 2009; 89: p. 122–125. doi: 10.2340/00015555-0591</mixed-citation><mixed-citation xml:lang="en">Naldi L., Parazzini F., Gallus S. et al. Prevalence of Atopic Dermatitis in Italian Schoolchildren: Factors Affecting its Variation //Acta Derm Venereol. 2009; 89: p. 122–125. doi: 10.2340/00015555-0591</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
