adairАллергология и Иммунология в ПедиатрииAllergology and Immunology in Paediatrics2500-11752712-7958Ассоциация детских аллергологов и иммунологов России10.53529/2500-1175-2024-3-54-64adair-156Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESРоль периостина как воспалительного маркера при бронхиальной астме у детейThe role of periostin as an inflammatory marker in bronchial asthma in childrenhttps://orcid.org/0000-0002-5533-0205БелыхН. А.BelykhN. A.

Белых Наталья Анатольевна — д. м. н., доцент, заведующая кафедрой факультетской и поликлинической педиатрии с курсом педиатрии

390026, г. Рязань, ул. Высоковольтная, д. 9

Natalia Anatolyevna Belykh — Dr. Sci., Associate Professor, Head of the Department of Faculty and Polyclinic Pediatrics with the Course of Pediatrics

390026, Ryazan, Vysokovoltnaya str., 9

nbelyh68@mail.ruhttps://orcid.org/0000-0002-9267-439XПизнюрИ. В.PisnyurI. V.

Пизнюр Инна Владимировна — ассистент кафедры факультетской и поликлинической педиатрии с курсом педиатрии

390026, г. Рязань, ул. Высоковольтная, д. 9

Inna Vladimirovna Pisnyur — Assistant of the Department of Faculty and Polyclinic Pediatrics with the Course of Pediatrics

390026, Ryazan, Vysokovoltnaya str., 9

innaabramova@yandex.ruhttps://orcid.org/0000-0001-9742-4528НикифоровА. А.NikiforovA. A.

Никифоров Александр Алексеевич — к. м. н., доцент, заведующий Центральной научно-исследовательской лабораторией

390026, г. Рязань, ул. Высоковольтная, д. 9

Alexander Alekseevich Nikiforov — Cand. Sci., Associate Professor, Head of the Central Research Laboratory

390026, Ryazan, Vysokovoltnaya str., 9

a.nikiforov@rzgmu.ruhttps://orcid.org/0000-0001-6296-9034НикифороваЛ. В.NikiforovaL. V.

Никифорова Лариса Владимировна — старший научный сотрудник Центральной научно-исследовательской лаборатории

390026, г. Рязань, ул. Высоковольтная, д. 9

Larisa Vladimirovna Nikiforova — Senior Researcher at the Central Research Laboratory

390026, Ryazan, Vysokovoltnaya str., 9

a.nikiforov@rzgmu.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Рязанский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииRyazan State Medical University2024071020240354–64Copyright © Белых Н.А., Пизнюр И.В., Никифоров А.А., Никифорова Л.В., 20242024Белых Н.А., Пизнюр И.В., Никифоров А.А., Никифорова Л.В.Belykh N.A., Pisnyur I.V., Nikiforov A.A., Nikiforova L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://adair.elpub.ru/jour/article/view/156

Актуальность. Белок внеклеточного матрикса периостин, экспрессируемый в ряде тканей организма, рассматривается в качестве маркера воспаления Т-клеток 2-го типа и контроля БА.Цель. Изучить взаимосвязь концентрации периостина в сыворотке крови в зависимости от степени тяжести бронхиальной астмы и показателей функции внешнего дыхания у детей.Материалы и методы. Проведено поперечное (одномоментное) исследование, куда были включены 80 детей в возрасте от 6 до 17 лет (средний возраст 12±3,2 года), которые были разделены на 2 группы: 1-я — дети с бронхиальной астмой (n=40); 2-я — группа сравнения (n=40). Концентрацию периостина в сыворотке крови определяли методом ИФА. Спирографическое исследование проводилось на компьютерном спирометре Spirolab 1, MIR (Италия).Результаты. Медиана (Ме) периостина в 1-й группе была в пределах нормы (730,2 нг/мл), но статистически значимо превышала показатель 2-й группы (539,7 нг/мл, р<0,05) и не зависела от возраста, длительности и степени тяжести БА, антропометрических показателей обследованных. Уровень периостина в сыворотке крови значимо коррелировал с частотой обострений заболевания в течение года (r=0,74, р=0,000), со статусом контроля астмы (r=0,32, р=0,04). Выявлена умеренная корреляция между уровнем периостина и ОФВ1 (r=−0,34; р=0,03).Заключение. У детей с БА медиана периостина в сыворотке крови возрастала пропорционально степени тяжести БА, контроля заболевания и частоты обострения заболевания.

Introduction. The extracellular matrix protein periostin, expressed in a number of body tissues, is considered as a marker of type 2 T cell inflammation and of asthma control.Objective. To study the relationship the serum periostin concentration in blood serum depending on the severity of asthma and indicators of respiratory function in children.Materials and methods. The cross-sectional (simultaneous) study included 80 children aged 6 to 17 years (average age 12±3.2), who were divided into 2 groups: 1st — children with asthma (n=40); 2nd — comparison group (n=40). The concentration of periostin in the blood serum was determined by the ELISA method. The spirographic study was performed on a computer spirometer Spirolab 1, MIR (Italy).Results. The Me of periostin in group 1 was within the normal range (730.2 ng/ml), but statistically significantly exceeded the indicator of group 2 (539.7 ng/ml, p<0.05) and did not depend on the age, duration and severity of asthma, anthropometric parameters of the examined. The level of periostin in the blood serum significantly correlated with the frequency of exacerbations of the disease during the year (r=0.74, p=0.000), with the status of asthma control (r=0.32, p=0.04). A moderate correlation was found between the level of periostin and FEV1 (r=−0.34; p=0.03).Conclusions. In children with asthma, the median periostin in the blood serum increased in proportion to the severity of asthma, disease control and the frequency of exacerbation of the disease.

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The authors declare that there are no conflicts of interest present.